| First Author | Cutforth T | Year | 2003 |
| Journal | Cell | Volume | 114 |
| Issue | 3 | Pages | 311-22 |
| PubMed ID | 12914696 | Mgi Jnum | J:101720 |
| Mgi Id | MGI:3604856 | Doi | 10.1016/s0092-8674(03)00568-3 |
| Citation | Cutforth T, et al. (2003) Axonal ephrin-As and odorant receptors: coordinate determination of the olfactory sensory map. Cell 114(3):311-22 |
| abstractText | Olfactory sensory neurons expressing a given odorant receptor (OR) project with precision to specific glomeruli in the olfactory bulb, generating a topographic map. In this study, we demonstrate that neurons expressing different ORs express different levels of ephrin-A protein on their axons. Moreover, alterations in the level of ephrin-A alter the glomerular map. Deletion of the ephrin-A5 and ephrin-A3 genes posteriorizes the glomerular locations for neurons expressing either the P2 or SR1 receptor, whereas overexpression of ephrin-A5 in P2 neurons results in an anterior shift in their glomeruli. Thus the ephrin-As are differentially expressed in distinct subpopulations of neurons and are likely to participate, along with the ORs, as one of a complement of guidance receptors governing the targeting of like axons to precise locations in the olfactory bulb. |
