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Allele : Tg(GFP/KRAS2/ALPP)1Brn transgene insertion 1, Anton Berns

Primary Identifier  MGI:2182853 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence, Reporter Gene  Tg(GFP/KRAS2/ALPP)1Brn
Strain of Origin  FVB/N Is Recombinase  false
Is Wild Type  false
molecularNote  A transgene consisting of a chicken beta actin promoter, followed by a GFP (green fluorescence protein) expression cassette flanked by two lox sites and preceding a human K-RasV12 cDNA combined with an ALPP (PLAP; human placenta-like alkaline phosphatase) expression construct. Expression of oncogenic K-RasV12 is dependent on Cre-mediated deletion of the GFP fragment.
  • mutations:
  • Insertion
  • synonyms:
  • <G12V>KRAS,
  • beta-actin::LSL::<G12V>KRAS,
  • beta-actin::LSL::<G12V>KRAS,
  • K-ras<G12V-IRES-PLAP-pA>,
  • <G12V>KRAS,
  • K-ras<G12V-IRES-PLAP-pA>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

8 Publication categories