Primary Identifier | MGI:2182853 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence, Reporter | Gene | Tg(GFP/KRAS2/ALPP)1Brn |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A transgene consisting of a chicken beta actin promoter, followed by a GFP (green fluorescence protein) expression cassette flanked by two lox sites and preceding a human K-RasV12 cDNA combined with an ALPP (PLAP; human placenta-like alkaline phosphatase) expression construct. Expression of oncogenic K-RasV12 is dependent on Cre-mediated deletion of the GFP fragment. |