| First Author | Tuovinen H | Year | 2009 |
| Journal | Cell Immunol | Volume | 257 |
| Issue | 1-2 | Pages | 5-12 |
| PubMed ID | 19261265 | Mgi Jnum | J:148549 |
| Mgi Id | MGI:3845697 | Doi | 10.1016/j.cellimm.2009.01.012 |
| Citation | Tuovinen H, et al. (2009) gammadelta T cells develop independently of Aire. Cell Immunol 257(1-2):5-12 |
| abstractText | Mutations in the transcriptional regulator Aire disrupt thymic alphabeta T cell selection, causing in humans Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). However, it is not known whether Aire is needed for normal gammadelta T cell development. We show that Aire(-/-) mice have a normal frequency of gammadelta T cells, with TCR repertoire comparable to that of wild-type mice, and normal amount of TCR Cdelta mRNA in ileum and skin. gammadelta T cells did not express increased amounts of CD25 or display hyperproliferation, and were not involved in pathological salivary gland infiltrates. Lastly, the frequency of circulating gammadelta T cells was similar in APECED patients and healthy controls. These data indicate that gammadelta T cells develop independently of Aire and are unlikely to have a significant pathogenetic or protective role in APECED. The antigens responsible for gammadelta and alphabeta T cell selection are thus probably largely different. |
