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Publication : Local immune response to food antigens drives meal-induced abdominal pain.

First Author	Aguilera-Lizarraga J	Year	2021
Journal	Nature	Volume	590
Issue	7844	Pages	151-156
PubMed ID	33442055	Mgi Jnum	J:306867
Mgi Id	MGI:6710145	Doi	10.1038/s41586-020-03118-2
Citation	Aguilera-Lizarraga J, et al. (2021) Local immune response to food antigens drives meal-induced abdominal pain. Nature 590(7844):151-156

abstractText

Up to 20% of people worldwide develop gastrointestinal symptoms following a meal(1), leading to decreased quality of life, substantial morbidity and high medical costs. Although the interest of both the scientific and lay communities in this issue has increased markedly in recent years, with the worldwide introduction of gluten-free and other diets, the underlying mechanisms of food-induced abdominal complaints remain largely unknown. Here we show that a bacterial infection and bacterial toxins can trigger an immune response that leads to the production of dietary-antigen-specific IgE antibodies in mice, which are limited to the intestine. Following subsequent oral ingestion of the respective dietary antigen, an IgE- and mast-cell-dependent mechanism induced increased visceral pain. This aberrant pain signalling resulted from histamine receptor H1-mediated sensitization of visceral afferents. Moreover, injection of food antigens (gluten, wheat, soy and milk) into the rectosigmoid mucosa of patients with irritable bowel syndrome induced local oedema and mast cell activation. Our results identify and characterize a peripheral mechanism that underlies food-induced abdominal pain, thereby creating new possibilities for the treatment of irritable bowel syndrome and related abdominal pain disorders.

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