| First Author | Mellado Lagarde MM | Year | 2008 |
| Journal | Nat Neurosci | Volume | 11 |
| Issue | 7 | Pages | 746-8 |
| PubMed ID | 18516034 | Mgi Jnum | J:139363 |
| Mgi Id | MGI:3807815 | Doi | 10.1038/nn.2129 |
| Citation | Mellado Lagarde MM, et al. (2008) Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier. Nat Neurosci 11(7):746-8 |
| abstractText | Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and Tecta(DeltaENT/DeltaENT) mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from Tecta(DeltaENT/DeltaENT) mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification. |
