| First Author | Ma C | Year | 2015 |
| Journal | Proc Natl Acad Sci U S A | Volume | 112 |
| Issue | 35 | Pages | 11013-7 |
| PubMed ID | 26283373 | Mgi Jnum | J:226710 |
| Mgi Id | MGI:5698310 | Doi | 10.1073/pnas.1510119112 |
| Citation | Ma C, et al. (2015) Transforming growth factor-beta signaling is constantly shaping memory T-cell population. Proc Natl Acad Sci U S A 112(35):11013-7 |
| abstractText | The long-term maintenance of memory T cells is essential for successful vaccines. Both the quantity and the quality of the memory T-cell population must be maintained. The signals that control the maintenance of memory T cells remain incompletely identified. Here we used two genetic models to show that continuous transforming growth factor-beta signaling to antigen-specific T cells is required for the differentiation and maintenance of memory CD8(+) T cells. In addition, both infection-induced and microbiota-induced inflammation impact the phenotypic and functional identity of memory CD8(+) T cells. |
