| First Author | Charles DJ | Year | 1986 |
| Journal | Mutat Res | Volume | 160 |
| Issue | 3 | Pages | 243-8 |
| PubMed ID | 3960038 | Mgi Jnum | J:15476 |
| Mgi Id | MGI:63597 | Doi | 10.1016/0027-5107(86)90134-x |
| Citation | Charles DJ, et al. (1986) Enzyme-activity mutations detected in mice after paternal fractionated irradiation. Mutat Res 160(3):243-8 |
| abstractText | (101/E1 X C3H/E1)F1-hybrid male mice were exposed in a 24-h fractionation interval to either 3.0 + 3.0-Gy or 5.1 + 5.1-Gy X-irradiation, and mated to untreated Test-stock females. The offspring were examined for mutations at 7 recessive specific loci and for activity alterations of erythrocyte enzymes controlled presumably by 12 loci. No enzyme-activity mutant was found in 3610 F1-offspring of the control group. In the experimental groups, no mutant was detected in 533 (3.0 + 3.0 Gy) and 173 (5.1 + 5.1 Gy) offspring from postspermatogonial germ cells treated. After treatment of spermatogonia. I mutant in 3388 F1-offspring of the 3.0 + 3.0-Gy group, and 5 mutants in 3187 F1 offspring of the 5.1 + 5.1-Gy group were found. The mutants were all genetically confirmed. The frequency (expressed as mutants/locus/gamete) of enzyme-activity mutations is 2 (5.1 + 5.1-Gy group) to 10 (3.0 + 3.0-Gy group) times lower than the frequency of recessive specific-locus mutations. |
