Primary Identifier | MGI:2183523 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Pkd1 |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Part of exon 43, exon 44, and part of exon 45 were replaced with a neomycin resistance cassette in the reverse orientation via homologous recombination. The gene targeting event introduces a stop codon into exon 43. The mutant allele was confirmed in heterozygous and homozygous animals by Northern blot analysis. |