| First Author | Monks DA | Year | 2003 |
| Journal | Neuroendocrinology | Volume | 78 |
| Issue | 1 | Pages | 45-51 |
| PubMed ID | 12869799 | Mgi Jnum | J:118739 |
| Mgi Id | MGI:3700316 | Doi | 10.1159/000071705 |
| Citation | Monks DA, et al. (2003) Steroid receptor coactivator-1 is not required for androgen-mediated sexual differentiation of spinal motoneurons. Neuroendocrinology 78(1):45-51 |
| abstractText | Steroid receptor coactivator-1 (SRC-1) amplifies genomic steroid hormone signal transduction and has been implicated in steroid-mediated sexual differentiation of the mammalian nervous system. We investigated the possible effect of an SRC-1 null mutation on 2 morphological endpoints of androgenic signaling: the number and size of motoneurons within the spinal nucleus of the bulbocavernosus (SNB). In wild-type C57/BL6 mice, SRC-1 immunoreactive nuclei were observed within the SNB and one of its target muscles, the levator ani. However, SRC-1 null mice were indistinguishable from sex-matched wild-type littermates in both SNB number and cross-sectional area of SNB motoneurons. Similarly, we found no difference between SRC-1 null and wildtype littermates in the number or size of motoneurons in the retrodorsolateral nucleus, a motor pool that is not typically sexually differentiated in either number or size. These results demonstrate that SRC-1 is not essential for the development and maintenance of a sexually dimorphic neuromuscular system. |
