| First Author | Korfhagen TR | Year | 1998 |
| Journal | Biochim Biophys Acta | Volume | 1408 |
| Issue | 2-3 | Pages | 296-302 |
| PubMed ID | 9813377 | Mgi Jnum | J:51270 |
| Mgi Id | MGI:1314956 | Doi | 10.1016/s0925-4439(98)00075-1 |
| Citation | Korfhagen TR, et al. (1998) Surfactant protein A (SP-A) gene targeted mice. Biochim Biophys Acta 1408(2-3):296-302 |
| abstractText | Mice lacking surfactant protein A (SP-A) mRNA and protein in vivo were generated using gene targeting techniques. SP-A (-/-) mice have normal levels of SP-B, SP-C and SP-D mRNA and protein and survive and breed normally in vivarium conditions. Phospholipid composition, secretion and clearance, and incorporation of phospholipid precursors are normal in the SP-A (-/-) mice. Lungs of SP-A (-/-) mice have markedly decreased tubular myelin figures and clear Group B streptococci and Pseudomonas aeruginosa less efficiently than SP-A wild type mice. These studies of SP-A (-/-) mice demonstrate that SP-A has an important role in the innate immune system of the lung in vivo. |
