| First Author | Mukherjee S | Year | 2012 |
| Journal | J Immunol | Volume | 188 |
| Issue | 9 | Pages | 4376-84 |
| PubMed ID | 22474025 | Mgi Jnum | J:188440 |
| Mgi Id | MGI:5440552 | Doi | 10.4049/jimmunol.1101775 |
| Citation | Mukherjee S, et al. (2012) Surfactant protein A modulates induction of regulatory T cells via TGF-beta. J Immunol 188(9):4376-84 |
| abstractText | TCR signaling plays a critical role in regulatory T cell (Treg) development. However, the mechanism for tissue-specific induction of Tregs in the periphery remains unclear. We observed that surfactant protein A (SP-A)-deficient mice have impaired expression of Foxp3 and fewer CD25(+)Foxp3(+) Tregs after ex vivo stimulation and after stimulation with LPS in vivo. The addition of exogenous SP-A completely reversed this phenotype. Although SP-A is known to inhibit T cell proliferation under certain activation conditions, both IL-2 levels as well as active TGF-beta levels increase on extended culture with exogenous SP-A, providing a key mechanism for the maintenance and induction of Tregs. In addition, kinetic suppression assays demonstrate that SP-A enhances the frequency of functional Foxp3(+) Tregs in responder T cell populations in a TGF-beta-dependent manner. In mice treated with LPS in vivo, Tregs increased approximately 160% in wild-type mice compared with only a 50% increase in LPS-treated SP-A(-/-) mice 8 d after exposure. Taken together, these findings support the hypothesis that SP-A affects T cell immune function by the induction of Tregs during activation. |
