| Primary Identifier | MGI:2183247 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Cldn1 |
| Transmission | Germline | Strain of Origin | 129S4/SvJae |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by replacement of exon 1, which encodes the first transmembrane domain and first extracellular loop, with a PGK-neo cassette facing the opposite orientation via homologous recombination. Absence of gene expression in homozygous mutant mice was confirmed by Northern blot analysis and immunofluorescent microscopy of liver tissues. |
