| First Author | Manent JB | Year | 2005 |
| Journal | J Neurosci | Volume | 25 |
| Issue | 19 | Pages | 4755-65 |
| PubMed ID | 15888651 | Mgi Jnum | J:128882 |
| Mgi Id | MGI:3768221 | Doi | 10.1523/JNEUROSCI.0553-05.2005 |
| Citation | Manent JB, et al. (2005) A noncanonical release of GABA and glutamate modulates neuronal migration. J Neurosci 25(19):4755-65 |
| abstractText | Immature neurons express GABA and glutamate receptors before synapse formation, and both transmitters are released at an early developmental stage. We have now tested the hypothesis that the ongoing release of GABA and glutamate modulates neuronal migration. Using 5-bromo-2'-deoxyuridine labeling and cocultures of hippocampal slices obtained from naive and green fluorescent protein-transgenic mice, we report that migration is severely affected by GABA(A) or NMDA receptor antagonist treatments. These effects were also present in munc18-1 knock-out slices in which soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent vesicular secretion of transmitters has been deleted. GABA(A) antagonists were more efficient than NMDA antagonists to reduce cell migration, in keeping with the earlier maturation of GABAergic mechanisms. We conclude that GABA and, to a lesser degree, glutamate released in a SNARE-independent mechanism exert a paracrine action on neuronal migration. |
