| First Author | Jaeschke A | Year | 2004 |
| Journal | Genes Dev | Volume | 18 |
| Issue | 16 | Pages | 1976-80 |
| PubMed ID | 15314024 | Mgi Jnum | J:91841 |
| Mgi Id | MGI:3050924 | Doi | 10.1101/gad.1216504 |
| Citation | Jaeschke A, et al. (2004) An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev 18(16):1976-80 |
| abstractText | The c-Jun NH2-terminal kinase (JNK) is activated during obesity. One consequence of obesity is that JNK phosphorylates the adapter protein insulin receptor substrate 1 (IRS-1) on Ser 307 and inhibits signaling by the insulin receptor. JNK can therefore cause peripheral insulin resistance during obesity and may contribute to the development of type 2 diabetes. Here we report that the JNK-interacting protein 1 (JIP1) scaffold protein, which binds components of the JNK signaling module, is essential for JNK activation in the adipose tissue of obese mice. These data identify JIP1 as a novel molecular target for therapeutic intervention in the development of obesity. |
