| First Author | Xie K | Year | 2010 |
| Journal | Nat Neurosci | Volume | 13 |
| Issue | 6 | Pages | 661-3 |
| PubMed ID | 20453851 | Mgi Jnum | J:161453 |
| Mgi Id | MGI:4459345 | Doi | 10.1038/nn.2549 |
| Citation | Xie K, et al. (2010) Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nat Neurosci 13(6):661-3 |
| abstractText | The type 5 G protein beta subunit (Gbeta5) can form complexes with members of the regulator of G protein signaling 7 (RGS7) family, but its relevance to neuronal G protein signaling is unclear. We found that mouse RGS7-Gbeta5 complexes bound to G protein-gated potassium channels and facilitated their functional coupling to GABA(B) receptors in neurons. Our findings identify a compartmentalization mechanism that is critical for ensuring high temporal resolution of neuronal G protein signaling. |
