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Publication : Depolarization induces calcium-dependent BMP4 release from mouse embryonic palate mesenchymal cells.

First Author  Follmer ML Year  2024
Journal  Nat Commun Volume  15
Issue  1 Pages  9806
PubMed ID  39532850 Mgi Jnum  J:358608
Mgi Id  MGI:7783080 Doi  10.1038/s41467-024-53642-2
Citation  Follmer ML, et al. (2024) Depolarization induces calcium-dependent BMP4 release from mouse embryonic palate mesenchymal cells. Nat Commun 15(1):9806
abstractText  Bone Morphogenetic Protein (BMP) signaling is essential for craniofacial development, though little is known about the mechanisms that govern BMP secretion. We show that depolarization induces calcium-dependent BMP4 release from mouse embryonic palate mesenchyme. We show endogenous transient changes in intracellular calcium occur in cranial neural crest cells, the cells from which embryonic palate mesenchyme derives. Waves of transient changes in intracellular calcium suggest that these cells are electrically coupled and may temporally coordinate BMP release. These transient changes in intracellular calcium persist in palate mesenchyme cells from embryonic day 9.5 to 13.5 mice. Disruption of a potassium channel called Kcnj2 significantly decreases the amplitude of calcium transients and the ability of cells to secrete BMP. Kcnj2 knockout mice have cleft palate and reduced BMP signaling. Our data suggest that temporal control of developmental cues is regulated by ion channels, depolarization, and intracellular calcium for mammalian craniofacial morphogenesis.
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