| First Author | Gianforcaro A | Year | 2012 |
| Journal | CNS Neurosci Ther | Volume | 18 |
| Issue | 7 | Pages | 547-57 |
| PubMed ID | 22591278 | Mgi Jnum | J:357695 |
| Mgi Id | MGI:7763894 | Doi | 10.1111/j.1755-5949.2012.00316.x |
| Citation | Gianforcaro A, et al. (2012) Dietary vitamin D3 supplementation at 10x the adequate intake improves functional capacity in the G93A transgenic mouse model of ALS, a pilot study. CNS Neurosci Ther 18(7):547-57 |
| abstractText | BACKGROUND: Vitamin D has antioxidant, anti-inflammatory, and neuroprotective properties, and may mitigate amyotrophic lateral sclerosis (ALS) pathology. AIMS: To determine the effects of dietary vitamin D(3) (D(3)) at 10-fold the adequate intake (AI) on functional and disease outcomes and lifespan in the transgenic G93A mouse model of ALS. METHODS: Starting at age 40 days, 32 G93A mice (21 M, 11 F) were provided ad libitum with either an adequate (AI; 1 IU/g feed) or high (HiD; 10 IU/g feed) D(3) diet. Differences were considered significant at P</= 0.10, as this was a pilot study. RESULTS: For paw grip endurance, HiD mice had a 7% greater score between 60-133 d versus AI mice (P= 0.074). For motor performance, HiD mice had a 22% greater score between 60-133 days (P= 0.074) versus AI mice due to changes observed in male mice, where HiD males had a 33% greater score (P= 0.064) versus AI males. There were no significant diet differences in disease onset, disease progression, or lifespan. CONCLUSION: Although disease outcomes were not affected, D(3) supplementation at 10-fold the AI improved paw grip endurance and motor performance in the transgenic G93A mouse model of ALS, specifically in males. |
