| First Author | Audet JN | Year | 2012 |
| Journal | PLoS One | Volume | 7 |
| Issue | 4 | Pages | e34932 |
| PubMed ID | 22523565 | Mgi Jnum | J:355715 |
| Mgi Id | MGI:6228070 | Doi | 10.1371/journal.pone.0034932 |
| Citation | Audet JN, et al. (2012) Ablation of proliferating cells in the CNS exacerbates motor neuron disease caused by mutant superoxide dismutase. PLoS One 7(4):e34932 |
| abstractText | Proliferation of glia and immune cells is a common pathological feature of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (i.c.v.) with the anti-mitotic drug cytosine arabinoside (Ara-C). I.c.v. delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS. Ara-C treatment caused substantial decreases in the number of microglia, NG2+ progenitors, Olig2+ cells and CD3+ T cells in the lumbar spinal cord of symptomatic SOD1(G93A) transgenic mice. Exacerbation of disease was also associated with significant alterations in the expression inflammatory molecules IL-1beta, IL-6, TGF-beta and the growth factor IGF-1. |
