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Allele : Tg(UcpDta)1Kz transgene insertion 1, Leslie P Kozak

Primary Identifier  MGI:2183746 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(UcpDta)1Kz
Strain of Origin  FVB/N Is Recombinase  false
Is Wild Type  false
molecularNote  Incorporation of a toxic transgene, diphtheria toxin-A-chain (Dta), coupled to regulatory elements of the gene for brown adipose tissue specific uncoupling protein (Ucp) resulted in the ablation of brown adipose tissue (BAT). Specifically, Dta was inserted into the first exon of Ucp1 at position +120 to create the vector.
  • mutations:
  • Insertion
  • synonyms:
  • BATless,
  • UCP-DTA,
  • BATless,
  • UCP-DTA
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

22 Publication categories