| First Author | Lim SL | Year | 2020 |
| Journal | Mol Neurobiol | Volume | 57 |
| Issue | 5 | Pages | 2447-2460 |
| PubMed ID | 32146679 | Mgi Jnum | J:324408 |
| Mgi Id | MGI:6881560 | Doi | 10.1007/s12035-020-01894-6 |
| Citation | Lim SL, et al. (2020) Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer's Disease-Like Neuropathology in Tg2576 Mice. Mol Neurobiol 57(5):2447-2460 |
| abstractText | Microglial dysregulation, pertaining to impairment in phagocytosis, clearance and containment of amyloid-beta (Abeta), and activation of neuroinflammation, has been posited to contribute to the pathogenesis of Alzheimer's disease (AD). Detailed cellular mechanisms that are disrupted during the disease course to display such impairment in microglia, however, remain largely undetermined. We hypothesize that loss of hematopoietic cell kinase (HCK), a phagocytosis-regulating member of the Src family tyrosine kinases that mediate signals from triggering receptor expressed on myeloid cells 2 and other immunoreceptors, impairs microglial homeostasis and Abeta clearance, leading to the accelerated buildup of Abeta pathology and cognitive decline during the early stage of neuropathological development. To elucidate the pivotal role of HCK in AD, we generated a constitutive knockout of HCK in the Tg2576 mouse model of AD. We found that HCK deficiency accelerated cognitive decline along with elevated Abeta level and plaque burden, attenuated microglial Abeta phagocytosis, induced iNOS expression in microglial clusters, and reduced pre-synaptic protein at the hippocampal regions. Our findings substantiate that HCK plays a prominent role in regulating microglial neuroprotective functions and attenuating early AD neuropathology. |
