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Allele : Cdkn2a<tm2.1Rdp> cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Ronald DePinho
Primary Identifier  MGI:2384177 Allele Type  Targeted
Attribute String  Null/knockout Gene  Cdkn2a
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 1 alpha, specific to the p16Ink4a alternative splice product, was replaced by a floxed neo cassette. Cre mediated recombination removed the floxed neo cassette. The absence of the p16Ink4a and the presence of p19ARF was confirmed by Western blot analysis of extracts from homozygous mutant mouse embryonic fibroblasts.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • p16-,
  • p16<Ink4a->,
  • p16<Ink4a->,
  • p16<Ink4a>-,
  • Ink4a<->,
  • Ink4a<->,
  • p16<Ink4a>-,
  • p16-
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

90 Publication categories





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