| First Author | Zhang L | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 8 | Pages | 749-55 |
| PubMed ID | 12101399 | Mgi Jnum | J:78180 |
| Mgi Id | MGI:2183684 | Doi | 10.1038/ni820 |
| Citation | Zhang L, et al. (2002) A nonredundant role for the adapter protein Shc in thymic T cell development. Nat Immunol 3(8):749-55 |
| abstractText | Signaling via the pre-T cell receptor (pre-TCR) regulates survival, proliferation, allelic exclusion and differentiation of thymocytes. The role played by the adapter protein Shc in T cells has remained controversial, and its role in pre-TCR signaling has not been addressed. We examined Shc function in thymic T cell development using two genetic approaches. Cre-loxP-mediated inducible expression in transgenic mice of a phosphorylation-defective mutant of Shc impaired signaling through the pre-TCR as well as subsequent proliferation and differentiation. Conditional deletion of the Shc locus in thymocytes also affected thymic maturation at the same pre-TCR developmental stage. Thus, both Shc expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T cell development. |
