| First Author | Miyasaka K | Year | 2002 |
| Journal | J Nutr | Volume | 132 |
| Issue | 4 | Pages | 739-41 |
| PubMed ID | 11925470 | Mgi Jnum | J:96087 |
| Mgi Id | MGI:3529388 | Doi | 10.1093/jn/132.4.739 |
| Citation | Miyasaka K, et al. (2002) Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor. J Nutr 132(4):739-41 |
| abstractText | Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety. We recently produced CCK-A, -B and AB receptor knockout mice to study the role of these receptors in energy metabolism. Daily energy intake and expenditure were significantly greater in CCK-BR(-/-) and CCK-AR(-/-)BR(-/-) mice than CCK-AR(-/-) and wild-type [CCK-AR(+/+)BR(+/+)] mice. Relative liver and kidney weights (g/kg body) were significantly greater in CCK-AR(-/-)BR(-/-) mice than in wild-type mice. Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown. |
