| First Author | Horinouchi Y | Year | 2004 |
| Journal | Eur Neuropsychopharmacol | Volume | 14 |
| Issue | 2 | Pages | 157-61 |
| PubMed ID | 15013032 | Mgi Jnum | J:101905 |
| Mgi Id | MGI:3605909 | Doi | 10.1016/S0924-977X(03)00103-2 |
| Citation | Horinouchi Y, et al. (2004) Reduced anxious behavior in mice lacking the CCK2 receptor gene. Eur Neuropsychopharmacol 14(2):157-61 |
| abstractText | Cholecystokinin 2 (CCK2) receptors have been implicated as mediators of anxiety in standard mouse models such as exploratory behavior both in black and white test boxes and in elevated plus-mazes. We investigated the role of the CCK2 receptor in anxiety by evaluating the behavior of mice lacking the gene for this receptor in these standard anxiety models (i.e., exploratory behavior in a black and white test box and exploratory behavior in an elevated plus-maze). In the black and white test box, mice lacking the CCK2 receptor gene showed significantly increased numbers of transitions between the boxes compared to control mice. In the elevated plus-maze, mice lacking the CCK2 receptor gene displayed significantly more head dips than control mice. These results suggest that mice lacking the CCK2 receptor gene are less anxious than normal mice. |
