| Primary Identifier | MGI:2384544 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Ins1-BCL2L1)1Ksp |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | 0.82 kb of human BCL2L1 cDNA preceded by 0.5 kb of rat insulin 1 promoter sequences was used for the transgene. Specific expression of the transgene in beta-cells of the pancreas was confirmed by immunohistochemical analysis. Protein staining was detected in beta-cells of transgenic animals, but not in non-beta-cells, liver, exocrine tissue, small intestine, or lymph nodes. Western blot analysis showed expression of the human protein was 2- to 3-fold that of endogenous protein. |
