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Allele : Tg(Ins1-BCL2L1)1Ksp transgene insertion 1, Kenneth S Polonsky
Primary Identifier  MGI:2384544 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Ins1-BCL2L1)1Ksp
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  0.82 kb of human BCL2L1 cDNA preceded by 0.5 kb of rat insulin 1 promoter sequences was used for the transgene. Specific expression of the transgene in beta-cells of the pancreas was confirmed by immunohistochemical analysis. Protein staining was detected in beta-cells of transgenic animals, but not in non-beta-cells, liver, exocrine tissue, small intestine, or lymph nodes. Western blot analysis showed expression of the human protein was 2- to 3-fold that of endogenous protein.
  • mutations:
  • Insertion
  • synonyms:
  • Fd 1 Bcl-xL,
  • Fd 1 Bcl-xL
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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3 Publication categories

Trail: Allele




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