| First Author | Takeuchi S | Year | 1998 |
| Journal | Cancer Res | Volume | 58 |
| Issue | 4 | Pages | 641-6 |
| PubMed ID | 9485015 | Mgi Jnum | J:45772 |
| Mgi Id | MGI:1196102 | Citation | Takeuchi S, et al. (1998) Strand specificity and absence of hot spots for p53 mutations in ultraviolet B-induced skin tumors of XPA-deficient mice. Cancer Res 58(4):641-6 |
| abstractText | We examined the spectrum of p53 mutations found in 40 UV- induced skin tumors of xeroderma pigmentosum group A gene (XPA)-deficient mice, p53 mutations were detected in 48% of the tumors, Nearly all of the mutations were induced at dipyrimidine sites, Ninety-three % of the mutations were G . C A . T transitions at dipyrimidine sites, including tandem transitions (CC-->TT), which are the hallmark of the UVB-induced mutation, Seventy-two % of the mutations at dipyrimidine sites could be ascribed to damage on the transcribed strand, In addition, no evident mutational hot spots were detected, This is in contrast to the UVB- induced skin tumors of normal mice, in which 92 % of p53 mutations occurred as a result of DNA damage on the nontranscribed strand, and clear hot spots were observed, Thus, XPA-deficient mice showed significant mutation features that might be characteristic of the absence of nucleotide excision repair and may provide a good animal model for the analysis of the high incidence of skin cancer in xeroderma pigmentosum group A patients. |
