| Primary Identifier | MGI:2383956 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Fabpl-RAC1-T17N)1Jig |
| Transmission | Chimeric | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| description | Transgenic animals exhibited abnormal morphology of jejunal crypt-villus units, inhibition of epithelial differentiation, and slowing of epithelial migration. |
| molecularNote | A human RAC1 gene carrying a dominant negative threonine to asparagine mutation at amino acid 17 was used for the transgene. Nucleotides -596 to +21 from rat Fabpl were used to drive expression of the transgene in intestinal epithelium. |
