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Allele : Tg(Fabpl-RAC1-T17N)1Jig transgene insertion 1, Jeffrey I Gordon
Primary Identifier  MGI:2383956 Allele Type  Transgenic
Attribute String  Dominant negative, Inserted expressed sequence Gene  Tg(Fabpl-RAC1-T17N)1Jig
Transmission  Chimeric Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
description  Transgenic animals exhibited abnormal morphology of jejunal crypt-villus units, inhibition of epithelial differentiation, and slowing of epithelial migration.
molecularNote  A human RAC1 gene carrying a dominant negative threonine to asparagine mutation at amino acid 17 was used for the transgene. Nucleotides -596 to +21 from rat Fabpl were used to drive expression of the transgene in intestinal epithelium.
  • mutations:
  • Insertion
  • synonyms:
  • Rac1Asn17,
  • Rac1Asn17
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Driven By

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3 Publication categories

Trail: Allele




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