| First Author | Iwaki T | Year | 2002 |
| Journal | Am J Pathol | Volume | 160 |
| Issue | 3 | Pages | 1021-34 |
| PubMed ID | 11891199 | Mgi Jnum | J:75302 |
| Mgi Id | MGI:2176298 | Doi | 10.1016/S0002-9440(10)64923-1 |
| Citation | Iwaki T, et al. (2002) Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. Am J Pathol 160(3):1021-34 |
| abstractText | In humans, maternal fibrinogen (Fg) is required to support pregnancies by maintaining hemostatic balance and stabilizing uteroplacental attachment at the fibrinoid layer found at the fetal-maternal junction. To examine relationships between low Fg levels and early fetal loss, a genetic model of afibrinogenemia was developed. Pregnant mice homozygous for a deletion of the Fg-gamma chain, which results in a total Fg deficiency state (FG(-/-)), aborted the fetuses at the equivalent gestational stage seen in humans. Results obtained from timed matings of FG(-/-) mice showed that vaginal bleeding was initiated as early as embryonic day (E)6 to 7, a critical stage for maternal-fetal vascular development. The condition of afibrinogenemia retarded embryo-placental development, and consistently led to abortion and maternal death at E9.75. Lack of Fg did not alter the extent or distribution pattern of other putative factors of embryo-placental attachment, including laminin, fibronectin, and Factor XIII, indicating that the presence of fibrin(ogen) is required to confer sufficient stability at the placental-decidual interface. The results of these studies demonstrate that maternal Fg plays a critical role in maintenance of pregnancy in mice, both by supporting proper development of fetal-maternal vascular communication and stabilization of embryo implantation. |
