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Allele : Ptpn1<tm1Bbk> protein tyrosine phosphatase, non-receptor type 1; targeted mutation 1, Barabra B Kahn

Primary Identifier	MGI:2384135	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Ptpn1
Transmission	Germline	Strain of Origin	129S4/SvJae
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 1 and surrounding sequence were replaced with a neomycin selection cassette. The absence of transcript and protein in homozygous mutant mice was verified by Northern and Western blot analyses of a variety of tissues.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
PTP-1B<->,
PTP1B<->,
Ex1<->,
PTP-1B<->,
PTP1B<->,
Ex1<->

earliestPublication:
Klaman LD, et al. (2000) Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20(15):5479-89

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

3 Carried By

0 Driven By

49 Publication categories

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