| First Author | Tersteegen A | Year | 2021 |
| Journal | Infect Immun | Volume | 89 |
| Issue | 6 | PubMed ID | 33753412 |
| Mgi Jnum | J:331520 | Mgi Id | MGI:7386975 |
| Doi | 10.1128/IAI.00026-21 | Citation | Tersteegen A, et al. (2021) Lymphotoxin beta Receptor: a Crucial Role in Innate and Adaptive Immune Responses against Toxoplasma gondii. Infect Immun 89(6) |
| abstractText | The lymphotoxin beta receptor (LTbetaR) plays an essential role in the initiation of immune responses to intracellular pathogens. In mice, the LTbetaR is crucial for surviving acute toxoplasmosis; however, until now, a functional analysis was largely incomplete. Here, we demonstrate that the LTbetaR is a key regulator required for the intricate balance of adaptive immune responses. Toxoplasma gondii-infected LTbetaR-deficient (LTbetaR(-/-)) mice show globally altered interferon-gamma (IFN-gamma) regulation, reduced IFN-gamma-controlled host effector molecule expression, impaired T cell functionality, and an absent anti-parasite-specific IgG response, resulting in a severe loss of immune control of the parasites. Reconstitution of LTbetaR(-/-) mice with toxoplasma immune serum significantly prolongs survival following T. gondii infection. Notably, analysis of RNA-seq data clearly indicates a specific effect of T. gondii infection on the B cell response and isotype switching. This study uncovers the decisive role of the LTbetaR in cytokine regulation and adaptive immune responses to control T. gondii. |
