| First Author | Arbore G | Year | 2019 |
| Journal | Life Sci Alliance | Volume | 2 |
| Issue | 3 | PubMed ID | 31097471 |
| Mgi Jnum | J:285506 | Mgi Id | MGI:6391714 |
| Doi | 10.26508/lsa.201800244 | Citation | Arbore G, et al. (2019) MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells. Life Sci Alliance 2(3) |
| abstractText | A fast antibody response can be critical to contain rapidly dividing pathogens. This can be achieved by the expansion of antigen-specific B cells in response to T-cell help followed by differentiation into plasmablasts. MicroRNA-155 (miR-155) is required for optimal T-cell-dependent extrafollicular responses via regulation of PU.1, although the cellular processes underlying this defect are largely unknown. Here, we show that miR-155 regulates the early expansion of B-blasts and later on the survival and proliferation of plasmablasts in a B-cell-intrinsic manner, by tracking antigen-specific B cells in vivo since the onset of antigen stimulation. In agreement, comparative analysis of the transcriptome of miR-155-sufficient and miR-155-deficient plasmablasts at the peak of the response showed that the main processes regulated by miR-155 were DNA metabolic process, DNA replication, and cell cycle. Thus, miR-155 controls the extent of the extrafollicular response by regulating the survival and proliferation of B-blasts, plasmablasts and, consequently, antibody production. |
