| First Author | Hu Q | Year | 2022 |
| Journal | Cell Rep | Volume | 40 |
| Issue | 1 | Pages | 111035 |
| PubMed ID | 35793628 | Mgi Jnum | J:342096 |
| Mgi Id | MGI:7314075 | Doi | 10.1016/j.celrep.2022.111035 |
| Citation | Hu Q, et al. (2022) Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response. Cell Rep 40(1):111035 |
| abstractText | During the early phase of primary humoral responses, activated B cells can differentiate into different types of effector cells, dependent on B cell receptor affinity for antigen. However, the pivotal transcription factors governing these processes remain to be elucidated. Here, we show that transcription factor Bach2 protein in activated B cells is transiently induced by affinity-related signals and mechanistic target of rapamycin complex 1 (mTORC1)-dependent translation to restrain their expansion and differentiation into plasma cells while promoting memory and germinal center (GC) B cell fates. Affinity-related signals also downregulate Bach2 mRNA expression in activated B cells and their descendant memory B cells. Sustained and higher concentrations of Bach2 antagonize the GC fate. Repression of Bach2 in memory B cells predisposes their cell-fate choices upon memory recall. Our study reveals that differential dynamics of Bach2 protein and transcripts in activated B cells control their cell-fate outcomes and imprint the fates of their descendant effector cells. |
