| First Author | Pham D | Year | 2013 |
| Journal | J Biol Chem | Volume | 288 |
| Issue | 38 | Pages | 27423-33 |
| PubMed ID | 23935104 | Mgi Jnum | J:203864 |
| Mgi Id | MGI:5528941 | Doi | 10.1074/jbc.M113.497248 |
| Citation | Pham D, et al. (2013) The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor alpha chain. J Biol Chem 288(38):27423-33 |
| abstractText | Cytokine responsiveness is a critical component of the ability of cells to respond to the extracellular milieu. Transcription factor-mediated regulation of cytokine receptor expression is a common mode of altering responses to the external environment. We identify the transcription factor Twist1 as a component of a STAT3-induced feedback loop that controls IL-6 signals by directly repressing Il6ra. Human and mouse T cells lacking Twist1 have an increased ability to differentiate into Th17 cells. Mice with a T cell-specific deletion of Twist1 demonstrate increased Th17 and T follicular helper cell development, early onset experimental autoimmune encephalomyelitis, and increased antigen-specific antibody responses. Thus, Twist1 has a critical role in limiting both cell-mediated and humoral immunity. |
