| First Author | Ohtsuka M | Year | 2004 |
| Journal | Biochem Biophys Res Commun | Volume | 314 |
| Issue | 3 | Pages | 849-53 |
| PubMed ID | 14741714 | Mgi Jnum | J:113607 |
| Mgi Id | MGI:3687086 | Doi | 10.1016/j.bbrc.2003.12.165 |
| Citation | Ohtsuka M, et al. (2004) Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model. Biochem Biophys Res Commun 314(3):849-53 |
| abstractText | We used Na(+)-Ca(2+) exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mice hearts after ischemia/reperfusion and the infarct size was significantly small in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury. |
