| First Author | Inoue O | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 1 | Pages | 81-7 |
| PubMed ID | 19059245 | Mgi Jnum | J:142694 |
| Mgi Id | MGI:3821962 | Doi | 10.1016/j.febslet.2008.11.026 |
| Citation | Inoue O, et al. (2009) Novel synthetic collagen fibers, poly(PHG), stimulate platelet aggregation through glycoprotein VI. FEBS Lett 583(1):81-7 |
| abstractText | Novel synthetic collagen fibers, poly(PHG) made by polycondensation of Pro-Hyp-Gly, spontaneously assume polymeric structure with molecular weights greater than 10(5). Its application for biomaterials has been explored, but that for a platelet agonist has not been investigated. Poly(PHG)-induced platelet aggregation independently of thromboxane A(2) and integrin alpha2beta1. Poly(PHG)-induced tyrosine phosphorylation of glycoprotein VI (GPVI)-related molecules and failed to activate GPVI/FcRgamma-deficient platelets. Binding of GPVI to poly(PHG) was confirmed by a surface plasmon resonance spectroscopy, suggesting that poly(PHG) activates platelets through GPVI. Poly(PHG) is an useful research tool to investigate GPVI-mediated signals and a substitute for collagen in platelet functional assays. |
