| First Author | Fruttiger M | Year | 1995 |
| Journal | Eur J Neurosci | Volume | 7 |
| Issue | 3 | Pages | 511-5 |
| PubMed ID | 7539694 | Mgi Jnum | J:106609 |
| Mgi Id | MGI:3619094 | Doi | 10.1111/j.1460-9568.1995.tb00347.x |
| Citation | Fruttiger M, et al. (1995) Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur J Neurosci 7(3):511-5 |
| abstractText | It has recently been shown that mice deficient in the gene for myelin-associated glycoprotein develop normal myelin sheaths in the peripheral nervous system. Here we report that in mutant mice older than 8 months the maintenance of axon-myelin units is disturbed, resulting in both axon and myelin degeneration. Morphological features include those typically seen in human peripheral neuropathies, where demyelination-induced Schwann cell proliferation and remyelination lead to the formation of so-called onion bulbs. Expression of tenascin-C, a molecule indicative of peripheral nerve degeneration, was up-regulated by axon-deprived Schwann cells and regenerating axons were occasionally seen. Myelin-associated glycoprotein thus appears to play a crucial role in the long-term maintenance of the integrity of both myelin and axons. |
