| First Author | Tourne S | Year | 1997 |
| Journal | Immunity | Volume | 7 |
| Issue | 2 | Pages | 187-95 |
| PubMed ID | 9285404 | Mgi Jnum | J:111238 |
| Mgi Id | MGI:3653321 | Doi | 10.1016/s1074-7613(00)80522-1 |
| Citation | Tourne S, et al. (1997) Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice. Immunity 7(2):187-95 |
| abstractText | According to past reports, H-2Ma0/0 mice express a single major histocompatiblity complex class II molecule, A(b), heavily loaded with a single peptide derived from the invariant chain, CLIP. Despite the highly restricted diversity of the class II:peptide complexes expressed on thymic stromal cells in the mutant animals, a large and diverse population of CD4+ T cells is positively selected. However, two important issues remained unresolved and are addressed here: Just how preponderant is CLIP occupancy of the class II molecules from H-2M0/0 mice? How extensive and functionally competent is the CD4+ population selected in the mutant animals? Our results argue that a single class II:peptide complex can select a very broad, though not complete, repertoire of CD4+ T cells. |
