Other
18 Authors
- Tandon R,
- Massion PP,
- Borczuk AC,
- Yang D,
- Zhu J,
- Sato T,
- Kong R,
- Lee E,
- Patel AS,
- Schadt EE,
- Sinha A,
- Chavez D,
- Powell CA,
- Altorki NK,
- Wang W,
- Ding B,
- Yoo S,
- Watanabe H
| First Author | Yoo S | Year | 2022 |
| Journal | Nat Commun | Volume | 13 |
| Issue | 1 | Pages | 1592 |
| PubMed ID | 35332150 | Mgi Jnum | J:322999 |
| Mgi Id | MGI:7260865 | Doi | 10.1038/s41467-022-29230-7 |
| Citation | Yoo S, et al. (2022) Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression. Nat Commun 13(1):1592 |
| abstractText | Here we focus on the molecular characterization of clinically significant histological subtypes of early-stage lung adenocarcinoma (esLUAD), which is the most common histological subtype of lung cancer. Within lung adenocarcinoma, histology is heterogeneous and associated with tumor invasion and diverse clinical outcomes. We present a gene signature distinguishing invasive and non-invasive tumors among esLUAD. Using the gene signatures, we estimate an Invasiveness Score that is strongly associated with survival of esLUAD patients in multiple independent cohorts and with the invasiveness phenotype in lung cancer cell lines. Regulatory network analysis identifies aurora kinase as one of master regulators of the gene signature and the perturbation of aurora kinases in vitro and in a murine model of invasive lung adenocarcinoma reduces tumor invasion. Our study reveals aurora kinases as a therapeutic target for treatment of early-stage invasive lung adenocarcinoma. |
