| First Author | Oikawa Y | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 18 | Pages | 3975-8 |
| PubMed ID | 15996660 | Mgi Jnum | J:99775 |
| Mgi Id | MGI:3583827 | Doi | 10.1016/j.febslet.2005.06.024 |
| Citation | Oikawa Y, et al. (2005) Protective role for cytosolic phospholipase A2alpha in autoimmune diabetes of mice. FEBS Lett 579(18):3975-8 |
| abstractText | Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) plays an important role in arachidonate pathway. To investigate the contribution of cPLA(2)alpha to autoimmune diabetes, we established non-obese diabetic (NOD) mouse, an excellent model for human type 1 diabetes, deficient in cPLA(2)alpha. These mice showed severe insulitis and a higher incidence of diabetes. In their macrophages, decreased prostaglandin E(2) (PGE(2)) induced by cPLA(2)alpha deficiency, and the increase in production of tumor necrosis factor (TNF)-alpha were observed. These results suggested that cPLA(2)alpha plays a protective role in progression of insulitis and development of autoimmune diabetes by suppression of TNF-alpha production from macrophages. |
