| Primary Identifier | MGI:2385790 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Sos2 |
| Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by replacement of a highly conserved exon (encoding amino acids 855-893 in the central portion of the CDC25-H domain) with a PGK-neo cassette via homologous recombination. Western blot analysis of tissues from homozygous mutant animals using antibodies directed against the N-terminal and C-terminal regions of the protein did not detect any form of gene expression. |
