| First Author | Costa MJ | Year | 2011 |
| Journal | J Biol Chem | Volume | 286 |
| Issue | 11 | Pages | 9063-70 |
| PubMed ID | 21228270 | Mgi Jnum | J:170642 |
| Mgi Id | MGI:4947007 | Doi | 10.1074/jbc.M110.164558 |
| Citation | Costa MJ, et al. (2011) Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate. J Biol Chem 286(11):9063-70 |
| abstractText | Glucocorticoids rapidly and robustly induce cell fate decisions in various multipotent cells, although the precise mechanisms of these important cellular events are not understood. Here we showed that glucocorticoids repressed Per3 expression and that this repression was critical for advancing mesenchymal stem cells to the adipocyte fate. Exogenous expression of Per3 inhibited adipogenesis, whereas knocking out Per3 enhanced that fate. Moreover, we found that PER3 formed a complex with PPARgamma and inhibited PPARgamma-mediated transcriptional activation via Ppargamma response elements. Consistent with these findings, Per3 knock-out mice displayed alterations in body composition, with both increased adipose and decreased muscle tissue compared with wild-type mice. Our findings identify Per3 as potent mediator of cell fate that functions by altering the transcriptional activity of PPARgamma. |
