| Primary Identifier | MGI:97899 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 19702 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables endopeptidase activity. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within positive regulation of blood pressure. Located in extracellular space. Is expressed in several structures, including adrenal medulla; embryo mesenchyme; medulla oblongata alar plate mantle layer; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). PHENOTYPE: Mice homozygous for a targeted null mutation are viable and fertile; no defects in the function of the renin-angiotensin system were detected and blood pressure regulation was normal. [provided by MGI curators] |
| specificity | The Ren2 gene is not found in the genome of the C57BL/6J strain, nor is it likely to be in the BALB/c or C3H/He strains. Strains it is present in include: AKR, CBA, DBA/2, ICR and Swiss. |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
