| First Author | Meixner A | Year | 2004 |
| Journal | EMBO J | Volume | 23 |
| Issue | 6 | Pages | 1325-35 |
| PubMed ID | 15029240 | Mgi Jnum | J:89085 |
| Mgi Id | MGI:3038054 | Doi | 10.1038/sj.emboj.7600133 |
| Citation | Meixner A, et al. (2004) JunD regulates lymphocyte proliferation and T helper cell cytokine expression. EMBO J 23(6):1325-35 |
| abstractText | Transgenic mice broadly expressing JunD (Ubi-junD(m)) appear phenotypically normal, but have strongly reduced numbers of peripheral lymphocytes. JunD overexpression in lymphocytes does not protect from numerous apoptotic insults; however, transgenic T cells proliferate poorly and exhibit impaired activation due to reduced levels of IL-4, CD25 and CD69. Consistently, in the absence of JunD (junD(-/-)) T cells hyperproliferate following mitogen induction. Moreover, transgenic T helper (Th) 2 cells have decreased IL-4 and IL-10 expression, whereas junD(-/-) Th2 cells secrete higher amounts of both Th2 cytokines. Th1-polarized junD(-/-) CD4(+) T cells display enhanced IFN-gamma cytokine production associated with upregulated T-bet expression and downregulated expression of suppressor of cytokine signaling-1. These novel findings demonstrate a regulatory role of JunD in T lymphocyte proliferation and Th cell differentiation. |
