| First Author | Ammirante M | Year | 2013 |
| Journal | Genes Dev | Volume | 27 |
| Issue | 13 | Pages | 1435-40 |
| PubMed ID | 23796898 | Mgi Jnum | J:199460 |
| Mgi Id | MGI:5502812 | Doi | 10.1101/gad.220202.113 |
| Citation | Ammirante M, et al. (2013) An IKKalpha-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence. Genes Dev 27(13):1435-40 |
| abstractText | Androgen-deprived prostate cancer (PCa) is infiltrated by B lymphocytes that produce cytokines that activate IkappaB kinase alpha (IKKalpha) to accelerate the emergence of castration-resistant tumors. We now demonstrate that infiltrating B lymphocytes and IKKalpha are also required for androgen-dependent expansion of epithelial progenitors responsible for prostate regeneration. In these cells and in PCa cells, IKKalpha phosphorylates transcription factor E2F1 on a site that promotes its nuclear translocation, association with the coactivator CBP, and recruitment to critical genomic targets that include Bmi1, a key regulator of normal and cancerous prostate stem cell renewal. The IKKalpha-BMI1 pathway is also activated in human PCa. |
