| First Author | Yokoyama S | Year | 2012 |
| Journal | Gene | Volume | 497 |
| Issue | 2 | Pages | 340-3 |
| PubMed ID | 22326531 | Mgi Jnum | J:183807 |
| Mgi Id | MGI:5319287 | Doi | 10.1016/j.gene.2012.01.024 |
| Citation | Yokoyama S, et al. (2012) Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice. Gene 497(2):340-3 |
| abstractText | Saturated fatty acids, acting as ligands for toll-like receptor 4 (TLR4), induce inflammation and mediate the development of insulin resistance. Myeloid differentiation factor 88 (MyD88) is an adaptor protein for TLR4. Previously, we found MyD88-deficient mice fed a high-fat diet (HFD) exhibited a severe diabetic phenotype. Stearoyl-CoA Desaturase 1 (SCD1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids and known as a risk factor of diabetes. In the present study, we found SCD1 was dramatically increased in HFD-fed MyD88-deficient mice liver. This finding showed the novel linkage between MyD88 and SCD1 in the development of diabetes mellitus. |
