| First Author | Miki H | Year | 2020 |
| Journal | J Immunol | Volume | 204 |
| Issue | 4 | Pages | 753-762 |
| PubMed ID | 31900344 | Mgi Jnum | J:284038 |
| Mgi Id | MGI:6388992 | Doi | 10.4049/jimmunol.1900180 |
| Citation | Miki H, et al. (2020) Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation. J Immunol 204(4):753-762 |
| abstractText | House dust mite (HDM) allergens are leading causes of allergic asthma characterized by Th2 responses. The lung-resident CD11b(+) dendritic cells (DCs) play a key role in Th2 cell development in HDM-induced allergic asthma. However, the regulatory mechanism of HDM-induced CD11b(+) DC activation remains incompletely understood. In this study, we demonstrate that mice deficient in an inhibitory immunoreceptor, Allergin-1, showed exacerbated HDM-induced airway eosinophilia and serum IgE elevation. By using bone marrow-chimeric mice that were sensitized with adoptively transferred HDM-stimulated wild-type or Allergin-1-deficient CD11b(+) bone marrow-derived cultured DCs (BMDCs), followed by challenge with HDM, we show that Allergin-1 on the BMDCs suppressed HDM-induced allergic airway inflammation. We also show that Allergin-1 suppressed HDM-induced PGE2 production from CD11b(+) BMDCs by inhibiting Syk tyrosine kinase activation through recruitment of SHP-1, subsequently leading to negative regulation of Th2 responses. These results suggest that Allergin-1 plays an important role in regulation of HDM-induced allergic airway inflammation. |
