| First Author | Pang IK | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 3 | Pages | 246-53 |
| PubMed ID | 23314004 | Mgi Jnum | J:193240 |
| Mgi Id | MGI:5468030 | Doi | 10.1038/ni.2514 |
| Citation | Pang IK, et al. (2013) IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus. Nat Immunol 14(3):246-53 |
| abstractText | Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8(+) T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus. |
