| First Author | Scanga CA | Year | 2004 |
| Journal | Infect Immun | Volume | 72 |
| Issue | 4 | Pages | 2400-4 |
| PubMed ID | 15039368 | Mgi Jnum | J:89001 |
| Mgi Id | MGI:3037589 | Doi | 10.1128/IAI.72.4.2400-2404.2004 |
| Citation | Scanga CA, et al. (2004) MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression. Infect Immun 72(4):2400-4 |
| abstractText | Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet mice with single TLR deletions are resistant to acute tuberculosis. MyD88(-/-) mice were used to examine whether TLRs play any role in protection against aerogenic M. tuberculosis H37Rv infection. MyD88(-/-) mice failed to control mycobacterial replication and rapidly succumbed. Moreover, expressions of interleukin 12, tumor necrosis factor alpha, gamma interferon, and nitric oxide synthase 2 were markedly decreased in the knockout animals. These results argue that resistance to M. tuberculosis must depend on MyD88-dependent signals mediated by an as-yet-undetermined TLR or a combination of TLRs. |
